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Symbol Name ID |
C3
complement component 3 MGI:88227 |
| Darker colors indicate more annotations |
| Human Phenotypes | Pancytopenia |
Abnormal erythrocyte enzyme concentration or activity |
Persistence of hemoglobin F |
Increased mean corpuscular volume |
Erythroid hyperplasia |
Reticulocytosis |
Anemia |
Hemolytic anemia |
Chronic hemolytic anemia |
Increased red cell sickling tendency |
Hypochromic anemia |
Iron deficiency anemia |
Microcytic anemia |
Target cells |
Leukocytosis |
Leukopenia |
Arterial thrombosis |
Thromboembolism |
Venous thrombosis |
Deep venous thrombosis |
Mesenteric venous thrombosis |
Thrombocytopenia |
Thrombocytosis |
Abnormality of the spleen |
Splenic infarction |
Splenomegaly |
| Disease(s) Associated with C3 | ||||||||||||||||||||||||||
| paroxysmal nocturnal hemoglobinuria | ||||||||||||||||||||||||||
| sickle cell anemia | ||||||||||||||||||||||||||
| systemic lupus erythematosus |
| Mouse Phenotypes | decreased susceptibility to autoimmune hemolytic anemia |
decreased mast cell number |
decreased neutrophil cell number |
abnormal neutrophil morphology |
decreased osteoclast cell number |
abnormal spleen germinal center morphology |
decreased spleen germinal center number |
decreased spleen germinal center size |
abnormal mast cell physiology |
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| Availability | Mouse Genotype | |||||||||
| C3tm1Crr/C3tm1Crr | ||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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